Growing Pennsylvania's High-Tech Economy: Choosing Effective Investments

Compares Pennsylvania's high-tech economic development incentives, programs, and taxes with those of six competitor states. Includes case studies, program summaries, and analyses using a proprietary model and database. Makes policy recommendations

The Crisis of the Midlist Author in American Book Publishing

On apprendra ici comment un syndicat aide les auteurs obscurs, ceux qui se trouvent «au milieu» du catalogue d'un éditeur, et qui sont les plus nombreux, à protéger leurs œuvres et leurs revenus. C'est lors de la signature de leur contrat qu'ils doivent comprendre les enjeux et limiter l'arbitraire des éditeurs, des grosses maisons surtout ; mais le but recherché est de signer des accords généraux sur quelques principes avec les éditeurs, comme l'ont fait les Britanniques.Mattera Philip. The Crisis of the Midlist Author in American Book Publishing. In: Revue Française d'Etudes Américaines, N°78, octobre 1998. L'édition américaine en mouvement. pp. 38-47

Prosperity lost/ Mattera

247 hal.; 24 cm

Are African business cycles synchronized? Evidence from spatio-temporal modeling

This paper investigates the business cycle synchronization in Africa, which is important for the definition of optimal monetary unions. Previous studies adopted either a cross-sectional or a time series approach, and this may have led to substantial variation in the findings for common business cycles across African countries. Considering fifty-two African economies, we study business cycles’ synchronization with a novel spatio-temporal hierarchical approach founded on the gravity model. The introduction of the spatial dimension is particularly relevant for Africa, where infrastructure constraints make monetary unions less feasible due to higher trading costs. We find positive evidence for the Economic Community of West African States (ECOWAS) and the Common Monetary Area (CMA) feasibility, while our results do not support the Central Africa CFA and the East African Monetary Union (EAMU) monetary unions.</p

Discordant Patterns of Genetic Variation at Two Chloroquine Resistance Loci in Worldwide Populations of the Malaria Parasite \u3ci\u3ePlasmodium falciparum\u3c/i\u3e

Mutations in the chloroquine resistance (CQR) transporter gene of Plasmodium falciparum (Pfcrt; chromosome 7) play a key role in CQR, while mutations in the multidrug resistance gene (Pfmdr1; chromosome 5) play a significant role in the parasite’s resistance to a variety of antimalarials and also modulate CQR. To compare patterns of genetic variation at Pfcrt and Pfmdr1 loci, we investigated 460 blood samples from P. falciparum infected patients from four Asian, three African, and three South American countries, analyzing microsatellite (MS) loci flanking Pfcrt (five loci [[1]40 kb]) and Pfmdr1 (either two loci [~5 kb] or four loci [~10 kb]). CQR Pfmdr1 allele-associated MS haplotypes showed considerably higher genetic diversity and higher levels of subdivision than CQR Pfcrt allele-associated MS haplotypes in both Asian and African parasite populations. However, both Pfcrt and Pfmdr1 MS haplotypes showed similar levels of low diversity in South American parasite populations. Median-joining network analyses showed that the Pfcrt MS haplotypes correlated well with geography and CQR Pfcrt alleles, whereas there was no distinct Pfmdr1 MS haplotype that correlated with geography and/or CQR Pfmdr1 alleles. Furthermore, multiple independent origins of CQR Pfmdr1 alleles in Asia and Africa were inferred. These results suggest that variation at Pfcrt and Pfmdr1 loci in both Asian and African parasite populations is generated and/or maintained via substantially different mechanisms. Since Pfmdr1 mutations may be associated with resistance to artemisinin combination therapies that are replacing CQ, particularly in Africa, it is important to determine if, and how, the genetic characteristics of this locus change over time